Outcomes of Acute Kidney Injury in Melioidosis: A Systematic Review and Meta-Analysis.

ABSTRACT: Background: Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, with high mortality rates, particularly in severe cases complicated by acute kidney injury (AKI). Objective: The objective of this study was to systematically review and quantitatively synthesize the impact of AKI on mortality and other clinical outcomes-including ICU admission and the need for renal replacement therapy (RRT)-in patients with melioidosis. Methods: A systematic search was conducted in PubMed, Scopus, and Embase up to 16 May 2025. Studies reporting mortality, ICU admission, or RRT use in patients with AKI were included. A random-effects meta-analysis was performed to estimate the odds ratio (OR) for mortality associated with AKI. Results: Twenty-nine

SUBMITTER: Klangbud WK 

PROVIDER: S-EPMC12299289 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature