A Novel <i>Closo</i>-<i>Ortho</i>-Carborane-Based Glucosamine Derivative as a Promising Agent for Boron Neutron Capture Therapy.

ABSTRACT: Background: Boron Neutron Capture Therapy (BNCT) is a promising cancer treatment that combines tumor-selective boron delivery agents with thermal neutrons to kill cancer cells while sparing normal tissue. BNCT requires boron-containing compounds that exhibit high tumor selectivity and achieve therapeutic boron concentrations within tumor cells. This work focuses on the early development of a novel boron cluster carbohydrate derivative based on the glucosamine structure. Our results indicate that this derivative may have advantages over the typical boron delivery agent used in clinical applications and may significantly improve boron delivery capacity at the cellular level. Methods: The performance of the compound in terms of boron uptake was tested in the U87-MG glioblastoma

SUBMITTER: Imperio D 

PROVIDER: S-EPMC12299632 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature