The Microbiological Characteristics and Genomic Surveillance of Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Isolated from Clinical Samples.

ABSTRACT: Klebsiella pneumoniae is a major public health concern due to its role in Gram-negative bacteremia, which leads to high mortality and increased healthcare costs. This study characterizes phenotypic and genomic features of K. pneumoniae isolates from clinical samples in Karachi, Pakistan. Among 507 isolates, 213 (42%) were carbapenem-resistant based on disk diffusion and MIC testing. Urine (29.7%) and blood (28.3%) were the most common sources, with infections predominantly affecting males (64.7%) and individuals aged 50-70 years. Colistin was the only antibiotic showing consistent activity against these isolates. The whole-genome sequencing of 24 carbapenem-resistant K. pneumoniae (CR-KP) isolates revealed bla_NDM-5 (45.8%) as the dominant carbapenemas

SUBMITTER: Rizvi M 

PROVIDER: S-EPMC12299758 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature