Exploratory Metabolomic and Lipidomic Profiling in a Manganese-Exposed Parkinsonism-Affected Population in Northern Italy.

ABSTRACT:

Background/objectives

Chronic manganese (Mn) exposure is a recognized environmental contributor to Parkinsonian syndromes, including Mn-induced Parkinsonism (MnIP). This study aimed to evaluate whole-blood Mn levels and investigate disease/exposure-status-related alterations in metabolomic and lipidomic profiles.

Methods

A case-control study (N = 97) was conducted in Brescia, Italy, stratifying participants by Parkinsonism diagnosis and residential Mn exposure. Whole-blood Mn was quantified using ICP-MS. Untargeted metabolomic and lipidomic profiling was conducted using LC-MS. Statistical analyses included Mann-Whitney U tests, conditional logistic regression, ANCOVA, and pathway analysis.

Results

Whole-blood Mn levels were significantly elevated in Parkinsonism cases

SUBMITTER: Lewis F 

PROVIDER: S-EPMC12299838 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature