Macroalgae-Inspired Brominated Chalcones as Cosmetic Ingredients with the Potential to Target Skin Inflammaging.

ABSTRACT: Skin aging is mainly caused by external factors like sunlight, which triggers oxidative stress and chronic inflammation. Natural halogenated flavonoids have demonstrated anti-inflammatory properties. Inspired by the macroalgae-derived bromophenol BDDE, we investigated the anti-inflammatory potential of structure-related chalcones (1-7). Chalcones 1 and 7 showed the least cytotoxicity in keratinocyte and macrophage cells. Chalcones 1, 2, 4, and 5 exhibited the most significant anti-inflammatory effects in murine macrophages after lipopolysaccharide stimulation, with chalcone 1 having the lowest IC₅₀ value (≈0.58 μM). A SNAP assay confirmed that chalcones do not exert their effects through direct NO scavenging.

SUBMITTER: Jesus A 

PROVIDER: S-EPMC12299847 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature