Amelioration of Metabolic Syndrome by Co-Administration of <i>Lactobacillus johnsonii</i> CRL1231 and Wheat Bran in Mice via Gut Microbiota and Metabolites Modulation.

ABSTRACT:

Background/objectives

Lactobacillus johnsonii CRL1231 (Lj CRL1231) is a strain with feruloyl esterase (FE) activity that enhances ferulic acid (FA) release from wheat bran (WB) and has potential as a probiotic for metabolic syndrome (MS). Given the potential health benefits of FA and its microbial metabolites, this study aimed to evaluate the therapeutic effect of Lj CRL1231 co-administered with WB in a mouse model of metabolic syndrome (MS) induced by a high-fat diet (HFD).

Methods

Mice were divided into three groups and fed for 14 weeks as follows: the Control group (standard diet), the MS group (HFD+WB), and the MS+Lj group (HFD+WB and Lj CRL1231-dose 10⁸ cells/day). Specifically, we analyzed the changes in the intestinal microbiota

SUBMITTER: Russo M 

PROVIDER: S-EPMC12299901 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature