Isolation and Characterization of Secondary Metabolites from <i>Hydractinia</i>-Associated Fungus, <i>Penicillium brevicompactum</i> MSW10-1, and Their Inhibitory Effects on Hepatic Lipogenesis.

ABSTRACT: Marine organism-associated microbes are an important source of structurally diverse and biologically active secondary metabolites exhibiting antimicrobial, anticancer, and anti-inflammatory activities. In this study, we investigated Penicillium brevicompactum MSW10-1, isolated from Hydractinia echinata, a marine invertebrate adapted to extreme intertidal and subtidal environments with variable temperature, salinity, and oxygen conditions. Through a combination of LC/MS-guided chemical analysis and chromatographic purification, eight secondary metabolites were isolated, including brevicolactones A (1) and B (2). The absolute chemical structures of 1 and 2 were determined based on NMR spectroscopic experiments, HR-ESIMS data, and quantum chemical ECD

SUBMITTER: Hwang HJ 

PROVIDER: S-EPMC12300214 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature