Oral Dysbiosis Is Associated with the Pathogenesis of Aortic Valve Diseases.

ABSTRACT: The involvement of oral bacteria in the pathogenesis of distant organs, such as the heart, lungs, brain, liver, and intestine, has been shown. We analyzed the distribution of bacterial species in the resected aortic valve by 16S rRNA metagenomic analysis and directly compared their gene sequences with those in the oral cavity. Thirty-two patients with aortic stenosis or aortic regurgitation who underwent aortic valve replacement were enrolled in this study. Antibody titer against periodontal pathogenic bacteria in the patient's serum was analyzed. The genetic background and distribution of bacterial species on subgingival plaque, the dorsal surface of the tongue, and the resected aortic valve were analyzed. Patients with aortic valve disease were shown to have more severe periodontal disea

SUBMITTER: Yaguchi E 

PROVIDER: S-EPMC12300341 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature