Detection of Feline Coronavirus RNA in Cats with Feline Infectious Peritonitis and Their Housemates.

ABSTRACT: Feline coronavirus (FCoV), the causative agent behind feline infectious peritonitis (FIP), is one of the biggest infectious threats to feline health. Despite this threat, the tissue distribution and viral RNA levels in cats infected with feline coronaviruses are poorly understood in the context of natural infection. Here, we used a two-step reverse-transcription quantitative PCR (RT-qPCR) to examine viral RNA levels from different sampling sites in both cats that have been clinically suspected of FIP and their feline housemates. We show that the distribution and amount of FCoV viral RNA does not differ between FCoV-infected cats with FIP and their feline housemates in blood, conjunctiva, or feces. Furthermore, in all FIP and non-FIP cases, viral RNA levels were higher in fecal samples than

SUBMITTER: Shepherd PM 

PROVIDER: S-EPMC12300432 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature