Exposure to Metal Mixtures and Metabolic Syndrome in Residents Living near an Abandoned Lead-Zinc Mine: A Cross-Sectional Study.

ABSTRACT: Information regarding the impact of polymetallic exposure on metabolic syndrome (MetS) among residents living near abandoned Pb-Zn mines is limited. Our objective was to investigate the impact of co-exposure to metal mixtures on the prevalence of MetS among residents. ICP-MS was used to measure the levels of 24 metals in the urine of 1744 participants, including 723 participants living near abandoned Pb-Zn mines, labeled as exposed area, and 1021 participants from other towns, labeled as reference area in the same city. Multivariable generalized linear regression, adaptive LASSO penalized regression, and BKMR were used to assess the associations between metals and MetS. The levels of eleven metals were higher, while those of nine metals were lower in the exposed area than those in the refe

SUBMITTER: Zhao M 

PROVIDER: S-EPMC12300448 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature