Temperature-Responsive and Self-Healing Hydrogel: A Novel Approach to Combat Postoperative Adhesions.

ABSTRACT: Postoperative adhesions are a prevalent complication following abdominal surgeries, often leading to significant clinical challenges. This study introduces an innovative solution utilizing a polyethylene glycol (PEG)-based triblock copolymer to form an injectable, self-healing hydrogel aimed at preventing these adhesions. The hydrogel, formulated with temperature-responsive and self-healing properties through the incorporation of poly (N-isopropyl acrylamide) (PNIPAM) and anion-pi interactions, was synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization. The hydrogel's physical properties, biocompatibility, hemostatic effect, and anti-adhesive capabilities were rigorously tested through in vitro and in vivo experiments involving rat models. It demonstrated

SUBMITTER: Zhan Y 

PROVIDER: S-EPMC12300532 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature