Revisiting the Genomic Epidemiology of Distinct Phage-Type <i>Vibrio cholerae</i> Strains Reveals Restricted Spatiotemporal Dissemination During an Epidemic.

ABSTRACT: The El Tor biotype of Vibrio cholerae caused the seventh cholera pandemic (7CP). Although V. cholerae variants of this biotype frequently emerge, studies on their microevolution and spatiotemporal transmission in epidemics caused by a single clone are limited. During the cholera outbreak in Sichuan Province, China, in the 1990s, strains belonging to phage type 6 (PT6) but resistant to typing phage VP5 due to a deletion mutation in ompW, which is the gene associated with the VP5 receptor were identified. In this study, we analyzed PT6 strains using genome sequencing to reveal the genomic and transmission characteristics of such a transient phage type in China's cholera epidemic history. The findings revealed that the PT6 strains formed an independent clone during the fo

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12300545 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature