Electrospun Parallel, Crossed Fibers for Promoting Cell Adhesion and Migration.

ABSTRACT: Electrospun fibers, possessing biomimetic characteristics similar to fibrous extracellular matrices, have attracted widespread attention as scaffold materials for skin tissue engineering. The topographical structure of electrospun fibers plays a critical role in determining cell behavior. However, the effects of fiber topography on human skin fibroblasts (HSFs) remain unclear. In this study, electrospinning technology was employed to investigate how parallel and crossed fiber architectures influence the spreading morphology, proliferation, and migration of HSFs. The results demonstrated that cells exhibited spindle-shaped elongation along single fibers; on closely spaced parallel fibers, cells formed cross-adhesions between adjacent fibers, with a fiber spacing of 30-60 μm serving as the t

SUBMITTER: Gao X 

PROVIDER: S-EPMC12300551 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature