Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus.

ABSTRACT: The crystal structure of a conserved hypothetical protein, Aq1575, from Aquifex aeolicus has been determined by using x-ray crystallography. The protein belongs to the domain of unknown function DUF28 in the Pfam and PALI databases for which there was no structural information available until now. A structural homology search with the DALI algorithm indicates that this protein has a new fold with no obvious similarity to those of other proteins of known three-dimensional structure. The protein reveals a monomer consisting of three domains arranged along a pseudo threefold symmetry axis. There is a large cleft with approximate dimensions of 10 A x 10 A x 20 A in the center of the three domains along the symmetry axis. Two possible active sites are suggested based on the structure and multip

SUBMITTER: Shin DH 

PROVIDER: S-EPMC123006 | biostudies-literature | 2002 Jun

REPOSITORIES: biostudies-literature