Polyelectrolyte Microcapsule-Assembled Colloidosomes: A Novel Strategy for the Encapsulation of Hydrophobic Substances.

ABSTRACT: The encapsulation of hydrophobic substances remains a significant challenge due to limitations such as low loading efficiency, leakage, and poor distribution within microcapsules. This study introduces a novel strategy utilizing colloidosomes assembled from polyelectrolyte microcapsules (PMCs). PMCs were fabricated via layer-by-layer (LbL) assembly on manganese carbonate (MnCO₃) or calcium carbonate (CaCO₃) cores, followed by core dissolution. A solvent gradient replacement method was employed to substitute the internal aqueous phase of PMCs with kerosene, enabling the formation of colloidosomes through self-assembly upon resuspension in water. Comparative analysis revealed that MnCO₃-based PMCs with smaller diameters (2.5-3 µm vs. 4.5-5.5 µm for CaCO₃

SUBMITTER: Musin EV 

PROVIDER: S-EPMC12300669 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature