Global Trends and Attributable Risk Factors in the Disease Burden of Lower Respiratory Infections.

ABSTRACT:

Background

Lower respiratory infections (LRIs) are the leading cause of the global disease burden, accounting for millions of deaths each year.

Methods

Data on LRIs, including deaths, disability-adjusted life years (DALYs), and incidence, were obtained from the Global Burden of Disease Study 2021. Joinpoint regression was employed to assess temporal trends in the LRIs' burden, while the age-period-cohort model was used to evaluate age, period, and cohort effects. Pearson's correlation coefficients were calculated to examine the relationship between DALYs attributable to risk factors and the socio-demographic index (SDI).

Results

Over recent decades, the average annual percentage change in age-standardized mortality rate, age-standardized DALYs rate, and age-standardiz

SUBMITTER: Yu E 

PROVIDER: S-EPMC12300696 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature