Designing Polymeric Multifunctional Nanogels for Photothermal Inactivation: Exploiting Conjugate Polymers and Thermoresponsive Platforms.

ABSTRACT: Background/Objectives: Photothermal therapy (PTT) is an emerging minimally invasive strategy in biomedicine that converts near-infrared (NIR) light into localized heat for the targeted inactivation of pathogens and tumor cells. Methods and Results: In this study, we report the synthesis and characterization of thermoresponsive nanogels composed of poly (N-isopropylacrylamide-co-N-isopropylmethylacrylamide) (PNIPAM-co-PNIPMAM) semi-interpenetrated with polypyrrole (PPy), yielding monodisperse particles of 377 nm diameter. Spectroscopic analyses-including ¹H-NMR, FTIR, and UV-Vis-confirmed successful copolymer formation and PPy incorporation, while TEM images revealed uniform spherical morphology. Differential scanning calorimetry establis

SUBMITTER: Velzi I 

PROVIDER: S-EPMC12300760 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature