Metagenome Analysis Reveals Changes in Gut Microbial Antibiotic Resistance Genes and Virulence Factors in Reintroduced Giant Pandas.

ABSTRACT: Antibiotic resistance has emerged as a critical global public health challenge. In this study, we employed metagenomic sequencing to analyze fecal samples from giant pandas (Ailuropoda melanoleuca) across three distinct stages-semi-wild, released, and wild populations-to investigate shifts in antibiotic resistance genes (ARGs) and virulence factors (VFs) during the reintroduction process. Our findings revealed significant variations in the composition of ARG and VF across different stages, with released and wild giant pandas exhibiting similar ARG and VF profiles. Further analyses identified that the increased abundance of ARGs and VFs in both released and wild individuals compared to semi-wild individuals was mainly from Pseudomonas. We hypothesized that the same geographic

SUBMITTER: Feng W 

PROVIDER: S-EPMC12300801 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature