Metabolic Disruptions in Zebrafish Induced by α-Cypermethrin: A Targeted Metabolomics Study.

ABSTRACT: The widespread application of pesticides in agriculture has raised increasing concerns regarding their ecological impact, particularly in aquatic environments. Among these, α-cypermethrin, a highly active isomeric form of cypermethrin, has been extensively used due to its potent insecticidal efficacy and low mammalian toxicity. However, its toxicity to non-target aquatic organisms remains insufficiently understood at the metabolic level. In this study, a targeted metabolomics approach was employed to investigate the biochemical effects of α-cypermethrin in adult zebrafish. Acute toxicity was first determined to establish sublethal exposure concentrations (0.15 µg/L and 1.5 µg/L), followed by a 48 h exposure under a controlled flow-through system. GC-MS/MS-based analysis quantified 395 meta

SUBMITTER: Ok HJ 

PROVIDER: S-EPMC12300848 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature