Inhibitory Activity of Compounds Obtained from <i>Streptomyces</i> Against <i>Trypanosoma cruzi</i>.

ABSTRACT: Chagas disease (ChD) caused by Trypanosoma cruzi remains a major public health concern, affecting approximately 8 million people worldwide. However, the number of undiagnosed cases is likely much higher. Existing treatments rely on benznidazole and nifurtimox which, despite their efficacy during the acute phase of infection, are often associated with severe side effects that can be life-threatening. As a promising alternative, actinomycetes-which are renowned for producing pharmacologically and industrially relevant metabolites-have demonstrated potent antimicrobial properties; however, their antiparasitic potential remains largely unexplored. This study evaluated the anti-trypanocidal activities of extracellular metabolites produced by Streptomyces thermocarboxydus strain Ch

SUBMITTER: Delgado-Garduno JA 

PROVIDER: S-EPMC12300863 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature