Genetic Variants Linked with the Concentration of Sex Hormone-Binding Globulin Correlate with Uterine Fibroid Risk.

ABSTRACT: In this study we searched for correlations between polymorphic variants that determine sex hormone-binding globulin concentration (SHBG_con) and uterine fibroids (UFs). The work was performed on a sample of 1542 women (569 with UFs and 973 without UFs [control]), from whom we obtained experimental data on the distribution of nine single-nucleotide polymorphisms (SNPs) affecting the SHBG_con (data confirmed in genome-wide association studies [GWASs]). When searching for associations with UFs, both the independent effects of SNPs and the effects of their SNP-SNP interactions (SNP-SNP_ints) were taken into account during the "deep study" of the functionality of seven important UF loci and 115 strongly linked [r² ≥ 0.80] variants (an in silico methodolo

SUBMITTER: Ponomarenko M 

PROVIDER: S-EPMC12301028 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature