<i>Staphylococcus epidermidis</i> in Acute Myeloid Leukemia: A Comparative Genomic Study Against Non-AML Isolates.

ABSTRACT: Bloodstream infections (BSIs) are a major cause of morbidity and mortality in acute myeloid leukemia (AML) patients undergoing induction chemotherapy. Staphylococcus epidermidis, typically a skin commensal, is increasingly recognized as a pathogen in these vulnerable individuals. This study investigated whether genomic differences exist between infectious and gastrointestinal colonizing S. epidermidis isolates from AML patients and how these compare to colonizing and infectious isolates from other patient groups and biogeographic sites. We analyzed 114 isolates-44 from AML patients (23 infections, 21 GI colonizers) and 70 from public datasets (34 infections, 36 colonizers). Stool samples underwent 16S rRNA sequencing and culture to identify colonization, while bloodstream iso

SUBMITTER: McMahon S 

PROVIDER: S-EPMC12301045 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature