A conceptual framework for human-AI collaborative genome annotation.

ABSTRACT: Genome annotation is essential for understanding the functional elements within genomes. While automated methods are indispensable for processing large-scale genomic data, they often face challenges in accurately predicting gene structures and functions. Consequently, manual curation by domain experts remains crucial for validating and refining these predictions. These combined outcomes from automated tools and manual curation highlight the importance of integrating human expertise with artificial intelligence (AI) capabilities to improve both the accuracy and efficiency of genome annotation. However, the manual curation process is inherently labor-intensive and time-consuming, making it difficult to scale for large datasets. To address these challenges, we propose a conceptual framework,

SUBMITTER: Li X 

PROVIDER: S-EPMC12301185 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature