Comparative efficacy and safety of induction therapy in solid organ transplantation: a systematic review and network meta-analysis.

ABSTRACT:

Objective

To comparatively evaluate the efficacy and safety of induction therapies in solid organ transplantation (SOT) using a Bayesian network meta-analysis (NMA).

Methods

Randomized controlled trials (RCTs) assessing induction therapies were systematically identified across major databases (up to November 20, 2024). The screening, data extraction, and risk of bias (ROB) assessment were independently conducted by two reviewers through standardized tools. Bayesian NMA synthesized outcomes, including rejection, graft/overall survival, and infection rates.

Results

Sixty-eight RCTs (9,626 patients) evaluating 12 therapies were included. Surface Under the Cumulative Ranking Area (SUCRA) probabilities identified alemtuzumab as the most effective agent for reducing rejecti

SUBMITTER: Sun J 

PROVIDER: S-EPMC12301192 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature