Associations between an inflammatory diet index and nonunion: a prospective study of 172,839 UK biobank participants.

ABSTRACT:

Purposes

This study utilizes prospective cohort data from the UK Biobank to investigate the association between the energy-adjusted dietary inflammation index (E-DII) and the development of fracture nonunion.

Methods

In this study, COX regression was used to analyze the correlation between E-DII and nonunion. Among 172,839 participants free of prior nonunion at baseline, 2,341 (1.4%) developed nonunion during a median follow-up of 14.2 years. E-DII scores, calculated from five separate 24-h dietary recall assessments, were used to quantify dietary inflammatory potential, with higher values indicating pro-inflammatory patterns.

Results

Multivariable-adjusted analyses revealed that participants with anti-inflammatory dietary patterns (E-DII < -1) exhibited a significant

SUBMITTER: Su J 

PROVIDER: S-EPMC12301200 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature