Effects of dietary fiber on Chinese children with functional constipation and targeted modification of gut microbiota and related metabolites.

ABSTRACT:

Background

Although dietary fiber is widely recommended for preventing and treating functional constipation (FC), clinical trial evidence remains limited and the efficacy has not been sufficiently tested in children.

Purpose

This study aimed to evaluate the effects of dietary fiber on FC symptoms, while identifying modulations in gut microbiota and associated metabolic changes.

Results

Between January 1, 2024, and June 1, 2024, a total of 60 patients diagnosed with FC were enrolled in the study across three centers; however, 54 children completed the study. The final cohort consisted of 28 boys and 26 girls, aged 6 to 12 years (mean age: 8.4 ± 1.8 years). Following the dietary fiber intervention, a significant increase in the frequency of complete spontaneous bowel mo

SUBMITTER: Xiao P 

PROVIDER: S-EPMC12301205 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature