Untargeted plasma metabolite detection in sudden sensorineural hearing loss: identifying key metabolic signatures.

ABSTRACT:

Background

Sudden sensorineural hearing loss (SSNHL) is a common otological disorder with complex etiologies and unclear pathophysiology. This study aimed to detect and analyze plasma metabolites in SSNHL, identify potential biomarkers, and uncover underlying metabolic mechanisms.

Methods

A cohort of 64 SSNHL, classified into four subtypes (low-frequency, high-frequency, flat and total deafness type), and 53 normal controls (NC) were recruited. Plasma samples were collected and analyzed by high-performance liquid chromatography-mass spectrometry (LC-MS). Metabolite profiling was performed, followed by multivariate statistical analyses, including orthogonal projections to latent structures-discriminant analysis (OPLS-DA) and partial least-squares discriminant analysis (PLS-DA

SUBMITTER: Ma R 

PROVIDER: S-EPMC12301207 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature