Genetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence Map.

ABSTRACT:

Objectives

This protocol outlines the development of a systematic evidence map (SEM) on genetic and epigenetic alterations associated with human prenatal tobacco exposure. The SEM will identify and synthetize epidemiological data on periconceptional and prenatal tobacco exposure associated with genetic (e.g., DNA damage) and epigenetic (e.g., DNA methylation) outcomes. Furthermore, it will describe the available evidence, highlight knowledge clusters, and identify gaps for future research.

Methods

Bibliographic databases and grey literature sources will be searched, complemented by reference mining. Predefined inclusion and exclusion criteria will guide study inclusion. Data extraction will include population, exposure, comparator, outcome, funding, study design, confounding

SUBMITTER: Reis AT 

PROVIDER: S-EPMC12301260 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature