Circulating miR-542-3p as a Prognostic Marker for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

ABSTRACT: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, particularly in Asia. Despite therapeutic advancements, the prognosis of HCC remains poor. MicroRNAs have emerged as potential biomarkers for HCC prognosis and therapeutic response. This systematic review and meta-analysis examined the association between circulating miR-542-3p levels and HCC progression. Seven studies on HCC and miR-542-3p were selected for the meta-analysis. miR-542-3p showed significant diagnostic potential for HCC prognosis and therapeutic evaluation. Two independent researchers performed data extraction and used the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) method to assess the quality and risk of bias of the included studies. After the meta-analysis, human miRN

SUBMITTER: Balakrishnan R 

PROVIDER: S-EPMC12301263 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature