Epidemiological, clinical, and molecular analysis of human adenovirus infections in hospitalized children with acute respiratory infections in Tianjin, China.

ABSTRACT:

Background

Human Adenovirus (HAdV) is a significant pathogen for acute respiratory infections(ARIs) in children. However, its epidemiological patterns, serotype distribution changes, and molecular mechanisms associated with severe pneumonia during and after the COVID-19 pandemic require further elucidation through large-scale and molecular typing studies.

Methods

This study used a retrospective cohort design to analyze 28060 respiratory specimens from Tianjin Children's Hospital from March 2022 to March 2024. HAdV detection and typing were performed through targeted high-throughput sequencing and PCR-based amplification of Penton, Hexon, and Fiber genes for phylogenetic analysis. Additionally, clinical data were compared to assess differences in clinical presentations among

SUBMITTER: Fang Y 

PROVIDER: S-EPMC12301308 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature