Identification of a preferred DNA binding sequence and novel regulon member for CadR in <i>Pseudomonas aeruginosa</i> PAO1.

ABSTRACT: Transition metals, such as cadmium (Cd) and zinc (Zn), can be detrimental to cell viability in excess. Bacteria contain conserved regulatory mechanisms to sense and respond to a variety of environmental stressors, such as an influx of metal cations. One such mechanism is the activation of metalloregulatory transcription factors that bind to cognate metal cofactors to induce a transcription regulatory response. Metalloregulatory transcription factor families, such as the ferric uptake regulator (FUR), mercury-resistant regulator (MerR), copper-sensitive operon repressor (CsoR), and diphtheria toxin regulator (DtxR), are found widespread throughout bacterial genomes. Often, these transcription factors bind a specific DNA sequence found in the promoter of regulated genes to exert their transc

SUBMITTER: Barrows JK 

PROVIDER: S-EPMC12301328 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature