Shengyu decoction ameliorates knee osteoarthritis by inhibiting endoplasmic reticulum stress via Piezo1 channels.

ABSTRACT:

Background

Shengyu decoction (SYD) is a classic and excellent prescription of traditional Chinese medicine (TCM). The innovative use of SYD by Chinese medical master Prof. Qi Shi in the treatment of knee osteoarthritis (KOA) has achieved considerable clinical outcomes. However, the current weakness is the lack of studies on the active ingredients and mechanisms of SYD.

Purpose

To evaluate the role of SYD in reducing KOA cartilage damage as well as to explore the active ingredients and mechanisms of SYD.

Methods

The KOA rat model and chondrocyte model were established. This study employed various molecular biology techniques to clarify the role of SYD in vivo and in vitro. The active ingredients and mechanisms of SYD were analyzed through ultra-high-perfo

SUBMITTER: Song X 

PROVIDER: S-EPMC12301362 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature