Functional brain activity in persistent postural-perceptual dizziness (PPPD) during galvanic vestibular stimulation reveals sensitization in the multisensory vestibular cortical network.

ABSTRACT: Persistent postural-perceptual dizziness (PPPD) is often preceded by vestibular disorders. We applied galvanic vestibular stimulation (GVS) and related stimulus-evoked activity to individual ratings of perceived motion for each stimulus and to perceived egomotion thresholds by GVS and behavioural parameters outside the scanner: levels of functional disability by standardized questionnaires, visual motion coherence, passive egomotion perception by chair rotation and quantitative postural stability. We hypothesized that the preceding vestibular disorder predisposes to abnormal brain excitability by vestibular stimulation. All participants showed normal vestibular function tests on quantitative testing. GVS with different intensities was applied to 28 patients and 28 age- and gender-matched h

SUBMITTER: Storm R 

PROVIDER: S-EPMC12301453 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature