Association between nitric oxide treatment and intraventricular hemorrhage among extremely preterm neonates in Switzerland, 2012-2020.

ABSTRACT: Inhaled nitric oxide (iNO) treatment is routinely used to treat newborns suffering from severe respiratory distress syndrome (RDS). While the treatment is established for term born infants, its safety and efficacy remain controversial among preterm born infants. A 2017 meta-analysis focusing on this population reported a nonsignificant increase in the occurrence of severe intraventricular hemorrhage (sIVH) if infants were treated with iNO. sIVH is a dreaded complication of extreme premature birth that impairs long-term neurodevelopment. In this study, we hypothesize that iNO treatment is associated with the occurrence of sIVH among extremely preterm born infants. We investigated the Swiss population of infants born extremely preterm (< 28 weeks gestation) from 2012-2020 in a retrospective

SUBMITTER: Dahinden D 

PROVIDER: S-EPMC12301464 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature