Causal Effects of Inflammatory Bowel Disease on Lung Function and Disease: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background and aims

The increasing prevalence of Crohn's disease (CD) and ulcerative colitis (UC)-the two main forms of inflammatory bowel disease (IBD)-has made these conditions a growing concern in global public health. While IBD primarily impacts the gastrointestinal tract, emerging evidence suggests its extraintestinal effects, especially on the respiratory system. The correlation between the lungs and the gastrointestinal system has drawn attention to the potential pulmonary complications in IBD patients. The causal link between IBD and lung function or related disease remains inconclusive.

Methods

Leveraging publicly available genome-wide association study (GWAS) data sets, we performed a two-sample Mendelian randomization analysis to investigate potential links betwee

SUBMITTER: Fu X 

PROVIDER: S-EPMC12301568 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature