Neurochemical Profiles of Prefrontal Cortex and Hypothalamus at 3 and 7 T During Controlled Euglycemia: Evaluation in a Cohort With Type 1 Diabetes.

ABSTRACT: With the increasing adoption of ultrahigh-field MRI scanners, there is a growing interest in migrating MRS studies from 3 to 7 T. Prior field comparisons of MRS in healthy volunteers demonstrated better reliability of quantification at 7 T, particularly for weakly represented metabolites. Neurochemical quantification has not been compared at 3 T versus 7 T in clinical cohorts and under controlled physiological conditions. In this exploratory study, we analyzed MRS data from the hypothalamus and prefrontal cortex volumes of interest (VOIs) that were collected from the same individuals with Type 1 diabetes at 3 and 7 T as a part of a larger study investigating cerebral responses to glycemic changes. Seventeen individuals underwent MRS during euglycemic clamps at both 3 T and 7 T, allowing us

SUBMITTER: Park YW 

PROVIDER: S-EPMC12301584 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature