Causal associations and shared genetic etiology between neurodegenerative diseases and constipation.

ABSTRACT:

Background

There is increasing evidence suggesting a correlation between neurodegenerative diseases (NDDs) and constipation; however, their genetic relationship and causal mechanisms remain inadequately elucidated.

Objective

We aim to investigate the causal link and shared genetic basis between NDDs and constipation.

Methods

We obtained summary statistics from large-scale genome-wide association studies, encompassing five NDDs, including Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Lewy body dementia (LBD), as well as constipation. The primary analysis employed five Mendelian randomization methods to evaluate causal effects, while linkage disequilibrium score regression (LDSC) and high-definition lik

SUBMITTER: Sun W 

PROVIDER: S-EPMC12301607 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature