Plasma Metabolites Link Non-Communicable Diseases to Increased White Matter Hyperintensities.

ABSTRACT:

Aims

Cerebral small vessel disease (CSVD) and non-communicable diseases (NCDs) are major global health burdens. White matter hyperintensities (WMH) are a key imaging feature of CSVD, but the relationship between WMH and NCDs, especially the role of plasma metabolites in this association, remains unclear. This study aims to elucidate this link.

Methods

This study included participants with WMH from the UK Biobank cohort and examined the prevalence of 29 common NCDs in this population. General linear regression was used to analyze the association between NCDs and WMH. Propensity score matching and elastic net regression identified plasma metabolites associated with NCDs. Mediation analysis was conducted to explore the role of these metabolites in the association between NCDs a

SUBMITTER: Wang N 

PROVIDER: S-EPMC12301696 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature