Comparison of visual and analytic methods of Alzheimer's disease pathologic staging.

ABSTRACT:

Introduction

Methods for standardizing positron emission tomography (PET) indices of β-amyloid (Aβ) (Centiloid [CL]) and tau (CenTauRz, CTRz) burden facilitates direct comparisons across radiotracers and supports in vivo biologic staging per the AT(N) (Aβ [A], tau [T], and neurodegeneration [N]) framework. In lieu of post mortem examination, visual interpretation is the most sensitive indicator of these pathologies. Here, we compared the performance of analytic and visual methods of AT(N) staging.

Methods

A total of 149 participants were imaged using Pittsburgh Compound B ([¹¹C]PiB), [¹⁸F]flortaucipir, and 3T magnetic resonance (MR) to compare visual and analytic methods of biologic staging of AD in terms of AT(N) status.

Results

CL quantificatio

SUBMITTER: Lopresti BJ 

PROVIDER: S-EPMC12301700 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature