Development and Evaluation of a Computable Phenotype for Normal Tension Glaucoma.

ABSTRACT:

Purpose

To develop a computable phenotype for normal tension glaucoma (NTG) to enhance disease identification from electronic health records (EHRs).

Design

Retrospective cohort study.

Subjects

Deidentified EHR data from an academic medical center identified 1851 patients aged ≥40 years, with glaucoma and available clinical notes.

Methods

Of these 1851 patients, 200 were randomly selected for a chart review to receive gold standard diagnoses. Four rule-based NTG computable phenotypes were developed and tested. Phenotype 1 relied on NTG International Classification of Diseases (ICD)-9 and ICD-10 codes. Phenotype 2 incorporated structured intraocular pressure (IOP) data and medication lists. Phenotype 3 used only structured IOP data. Phenotype 4 combined structure

SUBMITTER: Chan F 

PROVIDER: S-EPMC12301754 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature