Loss of integrin alpha7-mediated signaling induces a dendritic cell-like phenotype in macrophages cultured on laminin-211/221 isoforms.

ABSTRACT: Laminin comprises α/β/γ subunits and performs tissue-specific functions that control cellular behavior. Laminin-α2 chains are highly expressed in neural components such as glial and Schwann cells and in muscles. Macrophages play important roles in tissue homeostasis and repair, and laminins affect macrophage dynamics. Integrin α7, a transmembrane receptor crucial for regulating cell-matrix interactions, has a high affinity for laminin-α2, but its function in macrophages remains unknown. Here, we find that loss of integrin α7 signaling induces a dendritic cell (DC)-like phenotype in THP-1-derived macrophages and in primary monocytes-derived macrophages induced by granulocyte macrophage colony-stimulating factor cultured on laminin-α2 chains. Functional blocking of integrin α7 induced dendri

SUBMITTER: Yoshiba N 

PROVIDER: S-EPMC12301786 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature