Associations of Child Amygdala Development With Borderline Personality Symptoms During Adolescence.

ABSTRACT:

Background

The current understanding of the neural correlates of borderline personality disorder (BPD) is limited, but some evidence suggests that alterations in limbic structures play a role in adult BPD. The developmental course of structural neural differences in BPD is unknown. Whether there is specificity for structural alterations in BPD compared to other psychiatric presentations, such as major depressive disorder (MDD), remains unexplored. In the current study, we examined childhood trajectories of 2 limbic regions that have been implicated in BPD, hippocampal and amygdala volume, as they relate to adolescent BPD symptoms compared to MDD symptoms.

Methods

Participants (n = 175; 85 [48.6%] female) were from a 17-year longitudinal study of preschool depression. Partici

SUBMITTER: Constantino-Pettit A 

PROVIDER: S-EPMC12301846 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature