The Gut Microbiota Is Altered in Antidepressant-Free Depressed Patients and Is Associated With Depression Severity.

ABSTRACT: Interest in the microbiota-gut-brain axis is increasing, but data on the associations between the microbiota and major depressive disorder (MDD), particularly in relation to symptomatology and treatment response, remain scarce and inconsistent. This study aims at characterizing the gut microbiota of antidepressant-free MDD patients with a Major Depressive Episode (MDE) in comparison to healthy controls (HCs) and to investigate whether microbiota composition is associated with depression severity. Twenty-five adults with a current MDE, who had been antidepressant-free for at least 1 month, were evaluated for both depression severity and fecal microbiota composition using 16S rRNA sequencing. Their microbiota profiles were compared with those of twenty-eight HCs. Psychiatric assessments were

SUBMITTER: Cussotto S 

PROVIDER: S-EPMC12301870 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature