CMOS-fabricated dielectrophoretic chip with embedded 3D TiN nano-electrode arrays for sperm capture and sperm damage reduction.

ABSTRACT:

Introduction

This study developed an embedded 3D TiN nano-electrode arrays with a strong electric field and high biocompatibility for the effective capture of motile sperms. The chip integrates CMOS fabrication technology with a three-dimensional structural design, exhibiting both electrode-based dielectrophoresis and insulator-based dielectrophoresis characteristics. It provides a stable operating environment under strong electric fields with minimal Joule heating interference.

Methods

In the experiments, we evaluated the effects of different waveforms and capture spaces on the capture efficiency of boar and bovine sperms.

Results and discussion

The results showed that square waves improved capture efficiency by approximately10% and confirmed that the capture space m

SUBMITTER: Liao IH 

PROVIDER: S-EPMC12301885 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature