Designing parylene coating for implantable brain-machine interfaces.

ABSTRACT: Parylene is widely recognized as an effective candidate for encapsulating implantable bioelectronics due to its outstanding chemical stability, conformity and biocompatibility. However, its weak adhesion to inorganic substrates remains a significant challenge. Here, we explored various pre- and post-deposition treatments to enhance adhesion and stability of parylene coating for implantable brain-machine interfaces (BMIs). We utilized 0%, 0.5%, 1%, and 1.5% (v/v) 3-(trimethoxysilyl)propyl-methacrylate as an adhesion promoter for substrate treatment prior to deposition. Deposited samples were subsequently subjected to post-heat treatments at various temperatures. Samples were exposed to an in vitro accelerated aging bath at 87 °C for 7 days to assess their post-implantation durability

SUBMITTER: Ebrahimibasabi S 

PROVIDER: S-EPMC12301961 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature