<i>Coptis chinensis</i> shows distinct effects on hyperlipidemia and gut microbiota in high-fat diet induced mice with cold or hot syndrome.

ABSTRACT:

Objective

Coptis chinensis (Huanglian in Chinese, HL) is commonly utilized in clinical settings to counteract dyslipidemia in patients with hot syndrome. Its lipid-reducing efficacy has been consistently demonstrated in high-fat diet (HFD)-induced hyperlipidemic animal models. However, whether HL's efficacy differs in HFD-fed animals with hot or cold syndromes remains unclear. This study aims to discern the variations in the anti-hyperlipidemic effects of HL in HFD-fed mice with hot or cold syndromes.

Methods

HFD-induced C57BL/6 mice were subjected to cold or hot syndrome via two weeks of ice water (0 °C) and levothyroxine sodium (240 µg/kg) treatment, respectively. Then, an aqueous extract of HL was administered to the mice via oral gavage over the following four-wee

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12301969 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature