Efficacy and safety of combining a thiazide diuretic with a loop diuretic in decompensated heart failure: A systematic review and meta-analysis.

ABSTRACT:

Background

Acute decompensated heart failure (ADHF) often presents as congestion, typically treated with intravenous loop diuretics. However, prolonged use of this therapy may lead to resistance which can be overcome by adding a thiazide diuretic. Less is known about the safety of this combination.

Objectives

We aimed to perform a meta-analysis comparing the efficacy and safety of a loop monotherapy versus a combination of loop and thiazide.

Methods

We systematically searched PubMed, Embase, and Cochrane for randomized controlled trials (RCTs) and observational studies comparing patients with ADHF using only loop diuretics to those using a thiazide adjuvant therapy. Statistical analyses were conducted using R software (v 4.3.2) and a random-effects model was em

SUBMITTER: Bessa R 

PROVIDER: S-EPMC12301972 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature