Developmental riboflavin deficiency results in structural and functional changes in the neural retina and RPE.

ABSTRACT: The retina, a metabolically active tissue, relies on adequate flavin levels for optimal function. Our previous research demonstrated that ablation of RTBDN, a retina-specific riboflavin binding protein, plays a pivotal role in maintaining flavin levels, leading to progressive retinal degeneration. This raises the fundamental question of how riboflavin deficiency impacts retinal structure and function. We have previously evaluated an adult diet-induced model of riboflavin deficiency and showed that lack of flavins resulted in severe functional and structural deficits in the neural retina and retinal pigment epithelium with increased oxidative stress and metabolic dysregulation. Ariboflavinosis resulting from mutations in riboflavin transporters manifests early in life and is treatable with

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12301974 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature