Factors associated with active syphilis infection in US blood donors.

ABSTRACT:

Background

Syphilis is increasing globally, with limited monitoring of risk factors in asymptomatic, low-risk populations. Here, we investigate contemporary demographic and behavioral risk factors associated with active syphilis infection (ASI) in US blood donors.

Study design and methods

Beginning with donations in October 2020, four US blood centers implemented standardized risk factor interviews for ASI in blood donors as part of a larger case-control study. Logistic regression models were used to assess ASI associations with demographics and behaviors within 12 months before donation. A conceptual framework explored causal ASI pathways.

Results

Responses were obtained from 369 ASI cases and 868 controls; from all eligible cases, the enrollment rate was 16%. Risk f

SUBMITTER: Avelino-Silva VI 

PROVIDER: S-EPMC12302010 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature