Impact of Hypertension on Cancer Stage at Diagnosis Among French Women: The E3N Prospective Cohort.

ABSTRACT:

Introduction

Hypertension may delay the detection of metastatic cancers. We investigated the association between incident hypertension and the risk of metastatic onset among female cancer patients. We studied notably the role of anti-hypertensive treatment and the time between hypertension onset and cancer diagnosis in this association.

Methods

E3N is a French prospective population-based cohort that recruited 98,995 women in 1990. A total of 7844 incident invasive cancers were examined. We used multivariate logistic regression models to calculate odds ratios (OR) and their 95% confidence intervals (CI). We also used restricted cubic splines to evaluate the nonlinear dose-response associations between hypertension duration and the risk of metastatic onset (vs. localised stag

SUBMITTER: Auguste A 

PROVIDER: S-EPMC12302036 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature